Serotonin syndrome in the deployed setting
Related Experiment Video
Updated: Jun 5, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Timothy I Lawyer1, Jeremy Jensen, Randon S Welton
1Wright State University Boonschoft School of Medicine, Psychiatry Department, 627 S. Edwin C. Moses Blvd., Dayton, OH 45417, USA.
Abstract:
Serotonin syndrome is a potential side effect of some psychotropic medications in common use today. With over 8000 adverse events related to this condition in 2004 alone, this risk warrants further attention. The deployed environment presents a unique set of stressors and risks involved in treatment with any psychotherapeutic agent. The following case illustrates one incidence of rapid titration of a selective serotonin reuptake inhibitor (SSRI) (fluoxetine) contributing to the emergence of serotonin syndrome.
Related Concept Videos
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...
Antidepressant Drugs: MAOIs and Other Agents
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...