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Pregnancy and chronic kidney disease
John M Davison1, Marshall D Lindheimer
1Institute of Cellular Medicine and Royal Victoria Infirmary, Newcastle University, Newcastle upon Tyne, United Kingdom. J.M.Davison@newcastle.ac.uk
Seminars in Nephrology
|January 27, 2011
Summary
This review examines chronic renal disease in pregnancy, questioning current counseling based on serum creatinine and proposing updated chronic kidney disease classification guidelines. It also assesses preeclampsia prevalence and its impact on end-stage renal disease progression.
Area of Science:
- Nephrology
- Obstetrics & Gynecology
- Reproductive Medicine
Background:
- Chronic renal disease (CKD) poses significant risks during pregnancy.
- Current counseling for pregnant women with CKD often relies on serum creatinine levels.
Purpose of the Study:
- To review current guidelines for counseling and managing pregnant women with CKD.
- To evaluate recent research on the validity of estimated glomerular filtration rate (eGFR) and serum creatinine in CKD pregnancy.
- To assess the prevalence of preeclampsia in women with CKD and its effect on CKD progression.
Main Methods:
- Literature review of recent studies.
- Analysis of research questioning traditional counseling methods.
- Critique of studies on preeclampsia in CKD pregnancies.
Main Results:
- Emerging evidence challenges the reliability of eGFR and serum creatinine for CKD pregnancy counseling.
- The utility of CKD classification-based guidelines is under investigation.
- Preeclampsia prevalence and its association with accelerated CKD progression in pregnant women require further research.
Conclusions:
- There is a need to re-evaluate counseling strategies for pregnant women with CKD.
- Transitioning to CKD classification-based guidelines may improve patient care.
- Further research is crucial to understand the long-term renal outcomes for women with CKD and preeclampsia.
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