Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Post-necrotising enterocolitis pseudo-obstruction treated with Cisapride.

J M Vanderwinden1, M Dassonville, E Van der Veken

  • 1Département de Chirurgie Pédiatrique, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Belgium.

Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery in Infancy and Childhood
|October 1, 1990
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bismuth-based quadruple therapy versus standard triple therapy for the eradication of Helicobacter pylori in Belgium: a multicentre, non-blinded randomized, prospective study.

Acta gastro-enterologica Belgica·2024
Same author

Perioperative spleen embolization as a useful tool in laparoscopic splenectomy for simple and massive splenomegaly in children: a prospective study.

Surgical endoscopy·2016
Same author

Follow-up of Helicobacter pylori infection in children over two decades (1988-2007): persistence, relapse and acquisition rates.

Epidemiology and infection·2013
Same author

[Thoracoscopic surgery in children].

Revue medicale de Bruxelles·2011
Same author

Multicenter survey of routine determinations of resistance of Helicobacter pylori to antimicrobials over the last 20 years (1990 to 2009) in Belgium.

Journal of clinical microbiology·2011
Same author

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis.

Cell death and differentiation·2010

Cisapride effectively treated intestinal pseudo-obstruction (IPO) in a patient with necrotising enterocolitis (NEC), preventing further surgery and promoting growth. The patient remained symptom-free after Cisapride withdrawal.

Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Neonatal Medicine

Background:

  • Necrotising enterocolitis (NEC) is a severe gastrointestinal condition in neonates.
  • Surgical intervention for NEC can lead to complications like short bowel syndrome and intestinal pseudo-obstruction (IPO).
  • IPO presents as a functional obstruction without mechanical blockage, causing significant morbidity.

Observation:

  • A patient with grade III NEC developed segmental colic IPO post-surgery, resulting in severe failure to thrive.
  • The patient had a significantly shortened intestine, making further surgical intervention high-risk.
  • Symptoms included abdominal distention and poor weight gain, indicative of intestinal dysfunction.

Findings:

  • Treatment with Cisapride, an intestinal prokinetic agent, at 1 mg/kg/d dramatically improved IPO symptoms.

Related Experiment Videos

  • The patient experienced significant weight gain and intestinal adaptation during Cisapride therapy.
  • Following a 6-month treatment course, Cisapride was withdrawn, and IPO did not recur over a 2-year follow-up period.

    • Implications:

    • Cisapride offers a non-surgical therapeutic option for managing IPO in neonates with short bowel syndrome.
    • Early intervention with prokinetic agents may prevent further intestinal resection and improve long-term outcomes.
    • This case highlights the potential of pharmacological management in addressing functional gastrointestinal disorders post-NEC surgery.