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Updated: Jun 5, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
Control of NF-κB activity by proteolysis
Véronique Baud1, Emmanuel Derudder
1Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. veronique.baud@inserm.fr
Abstract:
NF-κB transcription factors are critical regulators of many biological processes such as innate and adaptive immune responses, inflammation, cell proliferation and programmed cell death. This versatility necessitates a highly complex and tightly coordinated control of the signaling pathways leading to their activation. Here, we review the role of proteolysis in the regulation of NF-κB activity, more specifically the contribution of the well-known ubiquitin-proteasome system and the involvement of proteolytic activity of caspases and calpains.
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