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[Methotrexate toxicity. Myths and facts]
1Department für Innere Medizin, Klinik für Innere Medizin II/Arbeitsbereich Rheumatologie, Universitätsklinik Halle (Saale), Halle (Saale), Germany. gernot.keyszer@medizin.uni-halle.de
Abstract:
Methotrexate (MTX) is a safe and well-tolerated drug for the treatment of rheumatic diseases, even if the strictest safety standards are considered. Initial apprehension as to severe pulmonary or hepatic side-effects has not been confirmed. The risk of infection is not elevated compared with other disease-modifying antirheumatic drugs. In addition, a mutagenic potential could not be demonstrated even after long-term application. Therefore, MTX will maintain its significant role in antirheumatic therapy also in the near future.
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