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Updated: Jun 4, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
The dose response of chromosome aberrations in human lymphocytes induced in vitro by very low-dose γ rays
Toshiyasu Iwasaki1, Yoshio Takashima, Toshikazu Suzuki
1Central Research Institute of Electric Power Industry, 2-11-1 Iwadokita, Komae-shi, Tokyo, Japan. iwasakit@criepi.denken.or.jp
Abstract:
This paper considers the dose-effect relationship for unstable chromosome aberration yields in human lymphocytes in very low-dose range. Data are presented for (60)Co γ-ray doses of 0, 10, 20, 40 and 1000 mGy. More than 5,000 metaphases were scored for each data point at the very low doses, and each cell was double-checked using a semi-automated metaphase finding/relocation system. Aberration yields of dicentrics plus centric rings followed an excellent linear dose response down to zero dose; the yields were significantly above the control frequency from 20 mGy.

