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Updated: Jun 4, 2026

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
Published on: April 30, 2019
[Modeling of processes of specialization and integration as a basis for development of multicellularity]
Abstract:
The formalized description of the procedure of division of labor as the most important invariant of progressing development is presented. The concept of histion is introduced--the element of the elementary unit that arises as a result of such division and represents the so far overlooked independent level of biological organization. Based on the division of labor there is proposed the theory of progressing development, which allows calculating the composition and structure of multitude of histions and constructing their model. It has been shown that development of these units obeys the periodic law and their classification looks like the periodic table whose parameters have biological meaning and are useful for measuring progressing development. The obtained results constitute the basis for the nomogenetic theory of the progressing development of multicellular organisms.
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