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Updated: Aug 19, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
Published on: September 5, 2018
[Theory of spatial organization of epithelial layers (using neuroepithelia as an example)]
1Institute of Evolutional Physiology and Biochemistry.
Abstract:
New principles of spatial organization of epithelial layers and highly productive approach for studying their tridimensional histoarchitecture have been proposed for the first time. This approach was based on conception of module structure of tissues and represents a family of topological and geometrical models of tissue structure and their experimental aprobation. This approach allows to create theoretical histology of epithelial layers, allowing to predict and define experimentally new variants of multi-row and multi-serie epithelia and to forecast their changes in development and pathology. According to this conception a family of new tridimensional tissue models was created. It was demonstrated that the structures studied are characteristics for real epithelial. Possibility of existence of a new type epithelia was predicted and a complex of new informative signs for their spatial organization was presented.
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