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Related Concept Videos

Development of Analytical Methods01:21

Development of Analytical Methods

An analytical methodology can be divided into four sequential steps: technique, method, procedure, and protocol. A technique is a scientific principle that rationalizes a specific phenomenon through chemical measurements. Adapting a technique for analyzing a sample of interest is termed a method. The procedure outlines the directions for performing the analysis via an analytical method. The protocol is the detailed guidelines on the procedure, which should be strictly followed to obtain the...
Quantitative Analysis01:12

Quantitative Analysis

Quantitative analysis is a technique for measuring the amount of specific constituents in a sample. When the sample's composition is unknown, qualitative analysis is performed first to identify its components, which ensures that the correct substances are measured during the quantitative phase.
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the method...
Qualitative Analysis01:10

Qualitative Analysis

Qualitative analysis is the process of identifying elements, ions, or compounds in an unknown sample. It is the first and most fundamental type of analysis based on the hierarchy of analytical goals. This hierarchy is significant as it provides a structured approach to scientific research, with qualitative analysis serving as the initial step, providing essential information before moving on to quantitative or other forms of analysis.
There are two main approaches to qualitative analysis:...
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Sample Preparation for Analysis: Overview01:21

Sample Preparation for Analysis: Overview

Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

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Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure
08:19

Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure

Published on: September 4, 2010

Analytical sciences.

Peter C Hauser1

  • 1Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel. peter.hauser@unibas.ch

Chimia
|January 29, 2011
PubMed
Summary
This summary is machine-generated.

Researchers are miniaturizing analytical techniques, focusing on detection challenges for accurate quantitation. Contactless conductivity detection is highlighted as a successful advancement in analytical chemistry.

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Area of Science:

  • Analytical Chemistry
  • Bioanalytical Sciences
  • Physical Chemistry

Background:

  • Miniaturization of analytical techniques presents significant challenges for quantitation.
  • The research group focuses on detection methods within miniaturized analytical systems.

Purpose of the Study:

  • To highlight advancements in miniaturized analytical techniques.
  • To showcase the application of various detection methods for quantitation.
  • To introduce contactless conductivity detection as a key area of research.

Main Methods:

  • Exploration of atomic and molecular spectroscopy.
  • Development of different electroanalytical methods.
  • Focus on contactless conductivity detection.

Main Results:

  • Contributions made to overcoming quantitation challenges in miniaturized systems.
  • Demonstrated success in contactless conductivity detection.
  • Successful application of diverse spectroscopic and electroanalytical techniques.

Conclusions:

  • Miniaturization of analytical techniques is feasible and advancing.
  • Contactless conductivity detection offers a promising approach for sensitive analytical measurements.
  • The research group has made significant contributions to the field of analytical and bioanalytical sciences.