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Updated: Jun 4, 2026

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
Published on: January 4, 2018
Reaction screening using a microreactor
Olivier Naef1, Mathieu Roch, Thierry Chappuis
1Ecole d'ingénieurs et d'architectes de Fribourg, Boulevard de Pérolles 80, CP 32, CH-1705 Fribourg. olivier.naef@hefr.ch
Abstract:
This article discusses the screening of chemical reactions using a microreactor equipped with infrared spectroscopy as online analytics. An esterification reaction has been optimized in continuous mode with the proposed setup. The esterification did not work well due to the material of the microreactor (stainless-steel 316Ti) that catalyzed the decomposition of formic acid. However, despite the occurrence of decomposition, an optimization could be achieved with this system.

