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Updated: Jun 4, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
TIP60 as a potential marker for the malignancy of gastric cancer
Kazuma Sakuraba1, Kazuaki Yokomizo, Atsushi Shirahata
1Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan.
Background:
Recently, it has been shown that the loss of the human histone acetyl transferase, TIP60, led to an accumulation of double-strand DNA breaks and has been linked to a growing number of cancer types.
Materials And Methods:
TIP60 expression levels were examined in 46 gastric cancer samples using a quantitative real-time polymerase chain reaction (QRT-PCR). Subsequently, clinicopathological data were correlated with the TIP60 expression score.
Results:
A down-regulation of the TIP60 gene was observed in 28 out of 46 (61%) specimens of primary gastric cancer. TIP60 down-regulation showed significant correlation with patient age (p=0.0224), depth of tumor invasion (p=0.0401) and lymph node metastasis (p=0.0481).
Conclusion:
The down-regulation of TIP60 is important for the malignant pathway of gastric carcinogenesis.
