Related Experiment Video

Updated: Jun 4, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Pierre Robin sequence: report of two cases

R J Hegde1, N R Mathrawala

  • 1Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital, Navi Mumbai, India. drrahulhegde@gmail.com

Journal of the Indian Society of Pedodontics and Preventive Dentistry
|January 29, 2011
PubMed

Insights

Pierre Robin sequence (PRS) is a congenital condition characterized by micrognathia, glossoptosis, and cleft palate. This study presents two cases where palatal obturators were used to address feeding difficulties in neonates with PRS.

Area of Science:

  • Craniofacial anomalies
  • Pediatric dentistry
  • Congenital malformations

Background:

  • Pierre Robin sequence (PRS) is a congenital condition resulting from first brachial arch malformation.
  • PRS is characterized by a triad of micrognathia (small jaw), glossoptosis (tongue falling back), and cleft palate.
  • Feeding difficulties are common in neonates diagnosed with PRS, particularly those with a complete cleft palate.

Observation:

  • Two cases of neonates diagnosed with Pierre Robin sequence are presented.
  • Both patients exhibited a complete cleft palate, contributing to feeding challenges.
  • The study focuses on the management of feeding issues in these infants.

Findings:

  • Palatal obturators were constructed for both neonates with PRS.
  • The construction of palatal obturators aimed to mitigate feeding problems associated with the condition.
  • This highlights a potential therapeutic approach for managing PRS-related feeding issues.

Implications:

  • Palatal obturators may offer a viable solution for improving feeding in infants with Pierre Robin sequence.
  • Early intervention with custom oral appliances can potentially improve nutritional intake and overall health outcomes.
  • Further research into the efficacy of palatal obturators in managing PRS is warranted.

More Related Videos

Robot-Assisted Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma02:37

Robot-Assisted Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma

Published on: December 15, 2023

Related Concept Videos

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Sanger Sequencing01:57

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
Signal Sequences and Sorting Receptors01:41

Signal Sequences and Sorting Receptors

Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...