Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Spontaneous narrative production in focal neurodegenerative disease" [Neuropsychologia 97 (2015) 158-171].

Neuropsychologia·2018
Same author

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.

Proceedings of the National Academy of Sciences of the United States of America·2018
Same author

Frontotemporal dementia.

Handbook of clinical neurology·2018
Same author

Increased subjective experience of non-target emotions in patients with frontotemporal dementia and Alzheimer's disease.

Current opinion in behavioral sciences·2018
Same author

Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.

Neurology·2018
Same author

The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2018

Related Experiment Video

Updated: Jun 4, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Neuroimaging in dementia.

Maria Carmela Tartaglia1, Howard J Rosen, Bruce L Miller

  • 1University of California, San Francisco Memory and Aging Center, San Francisco, California 94143, USA. ctartaglia@memory.ucsf.edu

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|January 29, 2011
PubMed
Summary
This summary is machine-generated.

Dementia diagnosis is improving with advanced brain imaging. New techniques offer molecular, structural, and metabolic characterization for better staging and treatment monitoring.

More Related Videos

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

Related Experiment Videos

Last Updated: Jun 4, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Dementia incidence is increasing with an aging population.
  • Dementia encompasses various neurodegenerative diseases like Alzheimer's and frontotemporal dementia, alongside secondary causes.
  • Current diagnosis relies on symptoms, with definitive diagnosis requiring pathology.

Purpose of the Study:

  • To highlight the evolving role of brain imaging in dementia diagnosis.
  • To emphasize the need for early differentiation of primary dementias for targeted treatments.
  • To explore how advanced imaging can characterize neurodegenerative disorders.

Main Methods:

  • Review of structural and functional brain imaging techniques.
  • Discussion of how imaging examines brain structure, biochemistry, metabolism, and function.
  • Exploration of new imaging technologies for molecular, structural, and metabolic characterization.

Main Results:

  • Major neurodegenerative disorders exhibit specific, identifiable imaging findings.
  • Advanced imaging techniques provide detailed characterization of the brain.
  • Imaging aids in understanding dementia pathophysiology and differentiating between types.

Conclusions:

  • Brain imaging is crucial for diagnosing and understanding various dementias.
  • New imaging modalities promise to revolutionize dementia diagnosis and patient management.
  • Molecular, structural, and metabolic imaging will improve diagnosis, staging, and treatment monitoring.