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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

Updated: Jun 4, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Immunoproliferative small intestinal disease (IPSID).

Shahid Pervez1, Khalid Mumtaz, Syed Siddiq Ullah

  • 1Department of Pathology, The Aga Khan University Hospital, Karachi. shahid.pervez@aku.edu

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|February 1, 2011
PubMed
Summary
This summary is machine-generated.

Immunoproliferative small intestinal disease (IPSID) often presents with abdominal pain and duodenal involvement. Early stages (A and B) respond to antibiotics, while advanced stages (C) require chemotherapy.

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Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
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Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pathology

Background:

  • Immunoproliferative small intestinal disease (IPSID) is a rare disorder affecting the small intestine.
  • Understanding its clinical spectrum, diagnostic features, and treatment outcomes is crucial for patient management.

Purpose of the Study:

  • To characterize the frequency, demographics, clinical presentation, endoscopic and histopathological findings.
  • To evaluate treatment strategies and outcomes for patients with IPSID.

Main Methods:

  • Retrospective analysis of 27 IPSID cases diagnosed and treated over 18 years.
  • Review of patient demographics, clinical symptoms, endoscopic images, and biopsy results.
  • Staging of disease (A, B, C) and assessment of treatment response.

Main Results:

  • IPSID predominantly affected males (M:F ratio 2.4:1) with a mean age of 28.7 years.
  • Abdominal pain and diarrhea were common (68.8%), with the duodenum being the primary site (62.5%).
  • Early-stage IPSID (A and B) showed good response to tetracycline, while advanced-stage (C) diffuse large B-cell lymphoma required CHOP chemotherapy.

Conclusions:

  • IPSID exhibits distinct clinical and pathological features, often involving the duodenum.
  • Antibiotic therapy is effective for early-stage IPSID, whereas advanced stages necessitate chemotherapy.