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Related Concept Videos

Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
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Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
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Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
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Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Updated: Jun 4, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)
09:39

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

Published on: July 15, 2011

[Familial histoid leprosy].

F Hali1, H Benchikhi, S Azzouzi

  • 1Service de dermatologie, vénéréologie, centre hospitalier Ibn Rochd, Casablanca, Morocco. halifouzia@yahoo.fr

Annales De Dermatologie Et De Venereologie
|February 1, 2011
PubMed
Summary
This summary is machine-generated.

Familial histoid leprosy, a rare form of lepromatous leprosy, presented in siblings. Early diagnosis and multidrug therapy led to a favorable outcome, suggesting a potential genetic link for this rare leprosy variant.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Genetics

Background:

  • Histoid leprosy is a rare anatomoclinical variant of lepromatous leprosy.
  • Familial occurrence of histoid leprosy is exceptionally rare, with limited documented cases.
  • This study investigates two siblings diagnosed with histoid leprosy, highlighting a potential familial predisposition.

Observation:

  • Two siblings, a 21-year-old sister and a 25-year-old brother, presented with multibacillary leprosy.
  • Clinical examination revealed characteristic erythematous papules, nodules, and subcutaneous nodules.
  • Histopathological analysis confirmed dermal-hypodermic infiltrates with numerous acid-fast bacilli (AFB) without globi.

Findings:

  • Both siblings responded exceptionally well to the WHO multidrug regimen for multibacillary leprosy.
  • No relapse of erythema nodosum leprosum was observed during a two-year follow-up period.
  • The distinct clinical and histopathological features of histoid leprosy were confirmed.

Implications:

  • Histoid leprosy requires specific differentiation from other forms of leprosy based on clinical and histopathological findings.
  • The familial occurrence suggests a possible genetic predisposition to histoid leprosy, warranting further genetic investigation.
  • Early diagnosis and appropriate multidrug therapy are crucial for favorable outcomes in histoid leprosy.