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Updated: Jun 4, 2026
Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
Outcome of continence procedures after failed endoscopic treatment with dextranomer-based implants (DEFLUX®)
I Alova1, M Margaryan, V Verkarre
1Pediatric Surgery Department, (Pr Y. Révillon) Hop Necker Enfants-Malades, 149 Rue de Sèvres, 75015 Paris, France.
Purpose:
To evaluate outcome of further continence procedures after failure of endoscopic injections of dextranomer-based bulking agent.
Materials And Methods:
From 1997, 89 children (3-18 years) and one young adult were treated for incontinence with 145 endoscopic injections of dextranomer. On evaluation, each patient was classified as: dry, significantly improved, or treatment failure. Eighty-five patients had at least 12 months of follow up. Out of 34 (40%) treatment failures, 24 patients had a subsequent bladder neck procedure: artificial urinary sphincter (7), bladder neck plasty (9), bladder neck closure (1), fascial sling (3). Six patients had further endoscopic treatment (including 2 after bladder neck plasty).
Results:
At surgery, Deflux(®) paste was easily identified with minimal surrounding tissue inflammatory reaction. Artificial urinary sphincter: all 7 dry; bladder neck plasty: 7 dry, 1 improved and 1 still incontinent; 1 bladder neck closure patient dry; fascial sling: 1 significantly improved and 2 dry. Repeated endoscopic treatment: 1 dry, 1 improved and 4 failed. Eleven of the 21 (52%) patients who are either dry or improved have voiding abilities.
Conclusion:
Endoscopic injections with dextranomer do not adversely affect the outcome of further surgical procedures. Repeated injections after a previous endoscopic treatment failure have a low success rate.
