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Updated: Feb 11, 2026
08:15
Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
Published on: May 22, 2019
10.7K
Nephron sparing surgery in tumours greater than 7cm
N de Saint Aubert1, F Audenet1, F Mccaig1
1Hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.
Summary
Partial nephrectomy (PN) offers similar oncologic outcomes to radical nephrectomy (RN) for larger tumors (cT2). While PN has higher complication rates, it preserves renal function, making it an acceptable option for carefully selected patients.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- Partial nephrectomy (PN) is standard for small renal tumors (<4cm).
- Limited data exists for PN in larger tumors (>7cm, cT2).
Purpose of the Study:
- To evaluate the outcomes of PN for clinical T2 (cT2) renal tumors.
- Compare PN with radical nephrectomy (RN) for cT2 tumors.
Main Methods:
- Retrospective review of 130 patients with cT2 tumors undergoing PN or RN (2000-2013).
- Comparison of demographics, renal function, morbidity, mortality, and oncologic outcomes.
- Statistical analysis using chi-squared, Mann-Whitney, Kaplan-Meier, and log-rank tests.
Main Results:
- 49 patients underwent PN, 81 underwent RN; median follow-up was 42 months.
- Postoperative renal function significantly better in the PN group (P=0.03, P<0.001).
- PN group had higher complication rates (37% vs. 14%, P=0.002), but similar oncologic outcomes (overall, recurrence-free, and cancer-specific survival).
Conclusions:
- PN is a viable option for cT2 renal tumors, providing comparable oncologic results to RN.
- Despite increased morbidity, PN's renal function preservation is a significant advantage.
- PN can be safely offered for cT2 tumors with acceptable outcomes.
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