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Related Experiment Video

Updated: Jun 4, 2026

Using a Cell-Tracer Injection to Investigate the Origin of Neointima-Forming Cells in a Rat Saccular Side Wall Model

Using a Cell-Tracer Injection to Investigate the Origin of Neointima-Forming Cells in a Rat Saccular Side Wall Model

Published on: March 16, 2022

NR4All in the vessel wall.

Claudia M van Tiel¹, Carlie J M de Vries

¹Academic Medical Center, K1-113, University of Amsterdam, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands.

The Journal of Steroid Biochemistry and Molecular Biology

|February 1, 2011

Summary

This summary is machine-generated.

The NR4A nuclear receptor subfamily, including Nur77, Nurr1, and NOR-1, plays a crucial role in vascular diseases like atherosclerosis. These proteins are key regulators in endothelial cells, smooth muscle cells, and immune cells within blood vessels.

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Related Experiment Videos

Last Updated: Jun 4, 2026

Using a Cell-Tracer Injection to Investigate the Origin of Neointima-Forming Cells in a Rat Saccular Side Wall Model

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Published on: March 16, 2022

Monitoring the Wall Mechanics During Stent Deployment in a Vessel

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Micropatterning and Assembly of 3D Microvessels

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Published on: September 9, 2016

Area of Science:

Vascular Biology
Molecular Endocrinology
Immunology

Background:

Nuclear receptors regulate normal vessel wall physiology.
Pathophysiological processes like atherosclerosis involve nuclear receptors.
The NR4A subfamily (Nur77, Nurr1, NOR-1) has emerging roles in vascular disease.

Purpose of the Study:

To review the function of NR4A nuclear receptors in vascular (patho)physiology.
To highlight the role of Nur77, Nurr1, and NOR-1 in vascular disease.
To examine NR4A involvement in endothelial cells, smooth muscle cells, and monocytes-macrophages.

Main Methods:

Comprehensive literature review.
Analysis of studies on NR4A subfamily members.
Focus on cellular mechanisms in vascular disease.

Main Results:

NR4A nuclear receptors are key regulatory proteins in vascular disease.
Evidence supports the involvement of Nur77, Nurr1, and NOR-1 in atherosclerosis, restenosis, and remodeling.
These receptors impact endothelial cells, smooth muscle cells, and monocytes-macrophages.

Conclusions:

The NR4A subfamily is critically involved in vascular cell function and disease.
Targeting NR4A receptors may offer therapeutic strategies for vascular conditions.
Further research into Nur77, Nurr1, and NOR-1 functions is warranted.