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Updated: Mar 19, 2026

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77
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Modulation of Nur77-DNA interactions by the glucocorticoid receptor

Laurens W H J Heling1,2, Kristina Kovač3, Carlie J M de Vries3,4,5

  • 1Medical Systems Biophysics and Bioengineering, Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

The Biochemical Journal
|March 18, 2026
PubMed
Summary

Glucocorticoid receptor (GR) stabilizes Nur77 DNA binding, while its ligand dexamethasone (Dex) reduces Nur77 DNA interaction frequency. This reveals distinct GR and Dex effects on Nur77 binding dynamics.

Keywords:
Nur77glucocorticoidscoidintrinsically disordered proteinsnuclear receptorstranscription factors

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