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Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

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Published on: May 9, 2011

Gene targeting MRI: nucleic acid-based imaging and applications.

Philip K Liu1, Christina H Liu

  • 1Department of Radiology, AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA. philipl@nmr.mgh.harvard.edu

Methods in Molecular Biology (Clifton, N.J.)
|February 1, 2011
PubMed
Summary

Researchers developed a novel MRI technique to non-invasively assess gene transcription in live brains. This method offers real-time insights into neurological disorders and aids therapeutic development.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Medical Imaging

Background:

  • Gene activity is crucial for brain function, influencing learning, stress, addiction, and neurological disorders like Alzheimer's.
  • Altered gene expression in neurons can precede cognitive decline by decades and contribute to mental illness comorbidities.
  • Understanding gene activity is vital for early intervention and developing new treatments for brain diseases.

Purpose of the Study:

  • To develop a non-invasive imaging technique for real-time assessment of gene transcription profiles in live brains.
  • To provide a tool for understanding the progression of neurological disorders through gene targeting and cell typing.
  • To identify potential surrogate markers for therapeutic efficacy in treating human brain diseases.

Main Methods:

  • Development of a non-invasive imaging technique.
  • Utilizing Magnetic Resonance Imaging (MRI) for real-time assessment.
  • Established a workable and reproducible MRI technique in live rodent brains.

Main Results:

  • A novel, non-invasive imaging method for assessing gene transcription in live brains has been established.
  • The technique allows for real-time monitoring of gene activity.
  • The MRI method is workable and reproducible in rodent models.

Conclusions:

  • This non-invasive imaging technique provides crucial real-time information on gene transcription in the brain.
  • It has the potential to advance the understanding and treatment of neurological disorders.
  • The method can aid in identifying therapeutic efficacy markers for future human treatments.