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Updated: Jun 4, 2026
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Multifunctional optical imaging using dye-coated gold nanorods in a turbid medium
Fuhong Cai1, Jun Qian, Li Jiang
1State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Centre for Optical and Electromagnetic Research, and Joint Research Center of Photonics of the Royal Institute of Technology (Sweden) and Zhejiang University, Zijingang Campus, Hangzhou 310058, China.
Dye-coated gold nanorods enable multifunctional optical imaging, detecting Raman, fluorescence, and absorption signals simultaneously. This novel nanoparticle shows promise as a versatile multimodality marker for advanced bioimaging applications.
Area of Science:
- Nanotechnology
- Optical Imaging
- Biomedical Engineering
Background:
- Gold nanorods offer unique optical properties.
- Multimodal imaging enhances diagnostic capabilities.
- Developing versatile contrast agents is crucial for bioimaging.
Purpose of the Study:
- To demonstrate multifunctional optical imaging using dye-coated gold nanorods.
- To evaluate the detection of Raman, fluorescence, and absorption signals.
- To assess the potential of these nanoparticles as multimodality markers.
Main Methods:
- Synthesis of dye-coated gold nanorods.
- Phantom experiments utilizing diffuse optical imaging.
- Detection of Raman scattering, fluorescence emission, and absorption contrast.
Main Results:
- Successfully obtained Raman signals, fluorescence signals, and absorption contrast from a single nanoparticle type.
- Demonstrated the feasibility of detecting these multiple signals using diffuse optical imaging in a phantom.
- Validated the multifunctional imaging capability of the developed nanoparticles.
Conclusions:
- Dye-coated gold nanorods serve as effective multimodal markers.
- This approach enables simultaneous acquisition of diverse optical information.
- The developed nanoparticles hold significant potential for future bioimaging applications.
