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Pattern and chemosensitivity of ovarian cancer in patients with BRCA1/2 mutations

K Ragupathy1, M Ferguson

  • 1Department of Oncology, Ninewells Hospital, Dundee, UK.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|February 2, 2011
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...