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Updated: Jun 4, 2026
13:26
Induction and Monitoring of Active Delayed Type Hypersensitivity (DTH) in Rats
Published on: July 19, 2007
Delayed hypersensitivity reaction to Restylane ® SubQ.
Philip O'Reilly1, Raman Malhotra
1Corneoplastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, UK. mrphiliporeilly@gmail.com
Orbit (Amsterdam, Netherlands)
|February 2, 2011
Summary
Four patients experienced delayed hypersensitivity reactions to Restylane(®) SubQ after facial volume augmentation. Hyaluronidase effectively resolved reactions, suggesting alternative non-animal stabilized hyaluronic acid (NASHA) products may be suitable.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Immunology
Background:
- Facial volume augmentation is commonly performed using non-animal stabilized hyaluronic acid (NASHA) fillers.
- Restylane(®) SubQ is a NASHA filler used for deep facial volume restoration.
Observation:
- Four patients presented with delayed hypersensitivity reactions to Restylane(®) SubQ.
- Reactions occurred between 1 week and 4 months post-treatment.
- Patients had no prior adverse reactions to other NASHA products.
Findings:
- Hypersensitivity reactions manifested as inflammatory responses to Restylane(®) SubQ.
- Hyaluronidase treatment resulted in rapid and effective resolution of symptoms.
- Two patients required repeat hyaluronidase injections for complete resolution.
Implications:
- Restylane(®) SubQ may trigger delayed hypersensitivity reactions in susceptible individuals.
- Hyaluronidase is a safe and effective treatment for these reactions.
- Patients experiencing reactions to Restylane(®) SubQ may tolerate other NASHA products.
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