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Updated: Jun 4, 2026

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

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Published on: December 31, 2007

Advances in basic and clinical immunology in 2010.

Javier Chinen¹, William T Shearer

¹Allergy and Immunology Section, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. jchinen@bcm.edu

The Journal of Allergy and Clinical Immunology

|February 2, 2011

Summary

Advances in immunology in 2010 included detailed B-cell biology, novel therapies like therapeutic monoclonal antibodies (mAbs), and improved outcomes for primary immunodeficiencies via newborn screening and stem cell transplantation.

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Published on: December 31, 2007

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

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Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Area of Science:

Basic and clinical immunology
Immunologic diseases
Novel therapies

Background:

B-cell biology detailed through genetic defects in humoral immunodeficiencies.
Therapeutic monoclonal antibodies (mAbs) like anti-CD20 (rituximab) expanded for autoimmune disorders.
Progress in understanding drug hypersensitivity mechanisms.

Purpose of the Study:

To summarize key advancements in immunology reported in 2010.
Highlight progress in understanding immunologic diseases and developing therapies.
Showcase improvements in diagnosing and treating primary immunodeficiencies.

Main Methods:

Utilized state-of-the-art genetic and immunologic tools.
Analyzed genetic defects in humoral immunodeficiencies.
Reviewed clinical data on hematopoietic stem cell transplantation outcomes.

Main Results:

Enhanced understanding of B-cell biology and humoral immunodeficiencies.
Successful application of therapeutic mAbs for various conditions.
Validated newborn screening for severe combined immunodeficiency (SCID) and improved transplant survival rates.
Identified drug metabolites as T-cell activators and dendritic cell relocation as a viral reactivation risk factor.

Conclusions:

Significant progress in characterizing immunologic diseases and developing targeted therapies.
Newborn screening and improved hematopoietic stem cell transplantation enhance outcomes for primary immunodeficiencies.
Further research into drug hypersensitivity and viral reactivation is warranted.