Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menses Phase01:18

Menses Phase

The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
The Menstrual Cycle01:19

The Menstrual Cycle

The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Histology of the Uterus01:19

Histology of the Uterus

The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GnRH agonist and hCG (dual trigger) versus hCG trigger for final follicular maturation: a double-blinded, randomized controlled study.

Human reproduction (Oxford, England)·2020
Same author

Human embryonic stem cells secrete soluble factors that inhibit cancer cell growth.

Cell proliferation·2009
Same author

Pinopodes: a questionable role in endometrial receptivity.

Human reproduction update·2008
Same author

Enhanced endocytotic and transcytotic activity in the rat endometrium prior to embryo implantation.

Journal of molecular histology·2008
Same author

Neutral mitochondrial heteroplasmy alters physiological function in mice.

Biology of reproduction·2007
Same author

Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure.

Cell death and differentiation·2006
Same journal

Impact of virtual case conferences between primary care clinicians and an interdisciplinary chronic pain clinic.

Canadian family physician Medecin de famille canadien·2026
Same journal

Canadian family physician Medecin de famille canadien·2026
Same journal

Predictors of high-performing family medicine clinics: Prospective cohort study in Alberta.

Canadian family physician Medecin de famille canadien·2026
Same journal

Acetylsalicylic acid use for artial fibrillation and bleeding risk.

Canadian family physician Medecin de famille canadien·2026
Same journal

Clinical practice guidelines: Important tools to teach the art of medicine.

Canadian family physician Medecin de famille canadien·2026
Same journal

Paratonia in advanced dementia: Challenges and evidence-based interventions.

Canadian family physician Medecin de famille canadien·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
06:22

Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

Published on: September 1, 2019

Dysfunctional uterine bleeding.

R F Casper

    Canadian Family Physician Medecin De Famille Canadien
    |February 2, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Early diagnosis of anovulation is crucial for managing dysfunctional uterine bleeding. Progestin therapy can prevent endometrial hyperplasia and heavy bleeding, while hysterectomy may be considered for persistent menorrhagia in women who have completed childbearing.

    Related Experiment Videos

    Last Updated: Jun 4, 2026

    Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis
    06:22

    Ex Vivo Method for Assessing the Mouse Reproductive Tract Spontaneous Motility and a MATLAB-based Uterus Motion Tracking Algorithm for Data Analysis

    Published on: September 1, 2019

    Area of Science:

    • Gynecology
    • Reproductive Endocrinology

    Background:

    • Dysfunctional uterine bleeding (DUB) is frequently linked to chronic anovulation.
    • Endometrial hyperplasia and severe bleeding can result from untreated anovulation.

    Purpose of the Study:

    • To emphasize the importance of early anovulation diagnosis.
    • To discuss management strategies for dysfunctional uterine bleeding.

    Main Methods:

    • Review of clinical associations and treatment outcomes for DUB.
    • Discussion of progestin therapy for anovulatory bleeding.
    • Consideration of hysterectomy for ovulatory menorrhagia.

    Main Results:

    • Progestin therapy, like Provera, can induce withdrawal bleeds, preventing endometrial hyperplasia.
    • The cause of DUB in ovulatory cycles remains unclear, with current treatments being experimental.
    • Hysterectomy is a viable option for anovulatory bleeding in women who have finished childbearing.

    Conclusions:

    • Prompt identification of anovulation is key to preventing complications of DUB.
    • Medical management focuses on hormonal regulation to control bleeding and prevent hyperplasia.
    • Surgical intervention like hysterectomy offers a definitive solution for severe, anovulatory menorrhagia in specific patient groups.