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A review of the antimicrobial activity of the fluoroquinolones
P Maple1, W Brumfitt, J M Hamilton-Miller
1Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, U.K.
Journal of Chemotherapy (Florence, Italy)
|October 1, 1990
Abstract:
The evolution of the fluoroquinolones is described, and structure-activity relationships outlined. The in-vitro antimicrobial activities of ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin against a wide range of organisms are critically reviewed. In-vitro factors influencing fluoroquinolone activity are discussed. Reports of the acquisition of resistance to the fluoroquinolones are evaluated. Finally, possible future directions for this group of antibiotics are discussed.