[Nucleotide pool of the brains of rats during different stages of dying]

Composition of acid-extractable fraction of nucleotides was studied in brain of dying rats after acute hemorrhage. Within the first 5 min content of ATP, GTP, UTP, GDP, UDP and NAD was distinctly decreased; content of AMP, GMP, IMP, CMP, nucleosides and nitrogen bases was markedly increased. Within the following 30 min of the dying rpocess concentration of CMP and nitrogen bases was increased but content of the other substances studied was decreased as compared with the previous experimental period. Possible effect of the alterations found on reanimation of an organism is discussed.