[Sandoglobulin immunocorrection in trauma].

Area of Science:

• Immunology
• Infectious Diseases
• Burn Care

Context:

• Patients with long-term compression syndrome (LCS) and severe burns often develop wound infections with altered immune responses.
• Immune dysregulation, including neutrophil respiratory burst and T-lymphocyte levels, is common in these patients.
• Current treatments may not fully address the complex immunological challenges in wound infections.

Purpose:

• To evaluate the efficacy of sandoglobulin in combination with antibacterial therapy for wound infections.
• To assess the impact of sandoglobulin on immunological parameters, body temperature, and leukogram shifts.
• To determine the optimal timing and conditions for sandoglobulin administration.

Summary:

• A study followed patients with long-term compression syndrome (LCS) and burns, all with wound infections, treated with sandoglobulin and antibiotics.
• Patients exhibited immune abnormalities, including altered neutrophil function and reduced active T-lymphocytes.
• Sandoglobulin treatment led to faster normalization of immunological indices, body temperature, and leukogram shifts, particularly in cases of acute microbial toxemia or severe burns.

Impact:

• Sandoglobulin demonstrated a significant positive effect on immune recovery in patients with severe wound infections.
• The findings suggest sandoglobulin can accelerate healing and improve patient outcomes in complex cases.
• A novel immunological monitoring procedure aids in identifying appropriate candidates for sandoglobulin therapy, alone or with other immunomodulators.