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Related Experiment Videos

[Sandoglobulin immunocorrection in trauma].

S M Belotskiĭ, V A Karlov, E V Gutsu

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |November 1, 1990
    PubMed
    Summary

    Sandoglobulin effectively normalized immunological indices in patients with wound infections, including long-term compression syndrome and severe burns. This immunomodulator accelerated recovery from infection and reduced inflammatory responses.

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    Erratum to: Novel pH-Sensitive Microbial Rhodopsin from Sphingomonas paucimobilis.

    Doklady. Biochemistry and biophysics·2021

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Burn Care

    Context:

    • Patients with long-term compression syndrome (LCS) and severe burns often develop wound infections with altered immune responses.
    • Immune dysregulation, including neutrophil respiratory burst and T-lymphocyte levels, is common in these patients.
    • Current treatments may not fully address the complex immunological challenges in wound infections.

    Purpose:

    • To evaluate the efficacy of sandoglobulin in combination with antibacterial therapy for wound infections.
    • To assess the impact of sandoglobulin on immunological parameters, body temperature, and leukogram shifts.
    • To determine the optimal timing and conditions for sandoglobulin administration.

    Summary:

    • A study followed patients with long-term compression syndrome (LCS) and burns, all with wound infections, treated with sandoglobulin and antibiotics.

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  • Patients exhibited immune abnormalities, including altered neutrophil function and reduced active T-lymphocytes.
  • Sandoglobulin treatment led to faster normalization of immunological indices, body temperature, and leukogram shifts, particularly in cases of acute microbial toxemia or severe burns.

    • Impact:

    • Sandoglobulin demonstrated a significant positive effect on immune recovery in patients with severe wound infections.
    • The findings suggest sandoglobulin can accelerate healing and improve patient outcomes in complex cases.
    • A novel immunological monitoring procedure aids in identifying appropriate candidates for sandoglobulin therapy, alone or with other immunomodulators.