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Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

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Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
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Published on: July 27, 2022

Bioactive composites for bone tissue engineering.

K E Tanner1

  • 1School of Engineering, James Watt South Building, University of Glasgow, Glasgow G12 8QQ, UK. elizabeth.tanner@glasgow.ac.uk

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
|February 4, 2011
PubMed
Summary
This summary is machine-generated.

Developing ideal bone tissue engineering scaffolds remains a challenge. This review covers current composite materials, production methods like porogen use and deposition, and assessment techniques including mechanical and in vivo testing.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Bone tissue engineering aims to create functional bone replacements.
  • Scaffold materials are critical for guiding bone regeneration.
  • Current limitations hinder the development of ideal bone scaffolds.

Purpose of the Study:

  • To review available composite scaffold materials for bone tissue engineering.
  • To discuss various production and assessment methodologies for bone scaffolds.
  • To highlight progress and remaining challenges in scaffold development.

Main Methods:

  • Literature review of composite materials for bone scaffolds.
  • Analysis of scaffold production techniques (e.g., porogens, deposition).
  • Examination of scaffold assessment methods (mechanical, in vivo).

Main Results:

  • Several composite material options exist for bone scaffolds.
  • Diverse production routes influence scaffold properties.
  • Mechanical and in vivo testing are crucial for evaluation.
  • No single ideal scaffold material has been identified yet.

Conclusions:

  • Significant advancements have been made in bone scaffold development.
  • Continued research is needed to overcome current limitations.
  • Optimizing material composition, production, and testing is key for future success.