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Related Experiment Video

Updated: Jun 4, 2026

Extraction of Tissue Antigens for Functional Assays

Extraction of Tissue Antigens for Functional Assays

Published on: September 10, 2012

Human insulin allergy: four case reports.

A Teixeira Rodrigues¹, L F Chiaverini Ensina, L Sabino Garro

¹Clinical Immunology and Allergy Service, Department of Internal Medicine, Hospital das Clínicas, University of São Paulo, Brazil. lfensina@yahoo.com.br

European Annals of Allergy and Clinical Immunology

|February 4, 2011

Summary

This summary is machine-generated.

Insulin allergy is rare but serious, even with human recombinant insulin. This study details 4 cases of IgE-mediated reactions, offering insights into diagnosis and treatment.

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Area of Science:

Allergy and Immunology
Endocrinology

Background:

Insulin allergy historically common, now rare due to human recombinant insulin.
Incidence of human recombinant insulin allergy is less than 1% of treated patients.
Despite rarity, insulin allergy necessitates prompt allergological evaluation.

Observation:

Presents 4 cases of IgE-mediated hypersensitivity to human recombinant insulin.
Highlights clinical scenarios of insulin allergy.
Focuses on practical diagnostic and therapeutic considerations.

Findings:

Confirms IgE-mediated mechanisms in human recombinant insulin allergy.
Illustrates the spectrum of allergic reactions.
Provides case-based evidence for diagnostic approaches.

Implications:

Underscores the importance of recognizing and managing rare insulin allergies.
Informs clinical practice regarding diagnosis and treatment strategies.
Contributes to understanding hypersensitivity to modern biopharmaceuticals.