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Microbiome and Asthma: What Have Experimental Models Already Taught Us?
R Bonamichi-Santos1, M V Aun1, R C Agondi1
1Clinical Immunology and Allergy Division, University of São Paulo School of Medicine, 01454-010 São Paulo, SP, Brazil.
Journal of Immunology Research
|August 13, 2015
Summary
Murine models have advanced our understanding of asthma pathogenesis and the microbiome's role in respiratory inflammation. These models are crucial for studying immune system development and inflammatory diseases.
Area of Science:
- Immunology
- Microbiology
- Pulmonology
Background:
- Asthma is a chronic inflammatory respiratory disease with significant public health impact.
- While allergic asthma pathogenesis is partly understood, gaps remain in knowledge.
- The human microbiome significantly influences immune system development and inflammatory disease occurrence.
Purpose of the Study:
- To review the evolution of murine models in asthma research.
- To explore key studies linking the microbiome to asthma.
- To understand the role of microbes in respiratory inflammation.
Main Methods:
- Review of historical and current experimental asthma models, focusing on murine models.
- Analysis of scientific literature on the microbiome and its connection to asthma.
- Examination of studies investigating microbial influence on respiratory inflammation.
Main Results:
- Murine models have been instrumental for over a century in studying asthma immunopathology.
- The microbiome plays a critical role in immune system development.
- Experimental models have elucidated the relationship between the microbiome and respiratory inflammation.
Conclusions:
- Murine models are essential tools for unraveling complex biological processes in asthma.
- Understanding the microbiome is key to comprehending asthma development and progression.
- Further research using these models can lead to novel therapeutic strategies for asthma.
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