Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Childhood ocular safety after postnatal exposure to topical dexamethasone during retinopathy of prematurity screening.

Acta ophthalmologica·2026
Same author

Academic achievement in children born extremely preterm: a cohort study.

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

External validation and updating of DIGIROP prediction models including parenteral nutrition for treatment-requiring retinopathy of prematurity in a Swedish national cohort.

BMJ open ophthalmology·2026
Same author

Long-Term Societal Costs After Births Before 24 Weeks of Gestation in Sweden.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same author

Low serum sphingosine-1-phospate and its chaperone ApoM associate with retinopathy of prematurity.

Journal of lipid research·2026
Same author

Neurodevelopmental Outcomes 12 Years After Extremely Preterm Birth in Sweden.

Pediatrics·2026

Related Experiment Video

Updated: Jun 4, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Postnatal decrease in circulating insulin-like growth factor-I and low brain volumes in very preterm infants.

Ingrid Hansen-Pupp1, Holger Hövel, Ann Hellström

  • 1Division of Pediatrics, Department of Clinical Sciences, Lund, Lund University Hospital, 221 85 Lund, Sweden. ingrid.pupp@skane.se

The Journal of Clinical Endocrinology and Metabolism
|February 4, 2011
PubMed
Summary
This summary is machine-generated.

Postnatal insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) levels are linked to larger brain volumes in very preterm infants. Supporting the IGF-I axis may aid normal brain development in this vulnerable population.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Related Experiment Videos

Last Updated: Jun 4, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Area of Science:

  • Neonatal Medicine
  • Developmental Neuroscience
  • Pediatric Endocrinology

Background:

  • Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are crucial for brain development.
  • Understanding their role in very preterm infants is vital for optimizing neurodevelopmental outcomes.

Purpose of the Study:

  • To investigate the association between postnatal serum IGF-I and IGFBP-3 concentrations and brain volumes at term-equivalent age.
  • To assess the relationship in infants born extremely preterm.

Main Methods:

  • Fifty-one very preterm infants (gestational age 26.4 weeks) were studied.
  • Weekly blood samples measured IGF-I and IGFBP-3 from birth to 35 weeks gestational age.
  • Brain volumes (total brain, cerebellum, gray matter, white matter) were assessed using MRI at 40 weeks gestational age.

Main Results:

  • Postnatal IGF-I and IGFBP-3 concentrations positively correlated with total brain, white matter, gray matter, and cerebellar volumes.
  • These associations persisted after adjusting for gestational age, nutrition, and other clinical factors.
  • Infants small for gestational age exhibited lower IGF-I levels and smaller brain volumes.

Conclusions:

  • Postnatal IGF-I and IGFBP-3 levels are significant positive predictors of brain volumes in very preterm infants.
  • Interventions aimed at normalizing the IGF-I axis may promote optimal brain development in this population.