Related Experiment Video
Updated: Jun 4, 2026

03:52
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
[Animal models for bone and joint disease. Rodent models of natural aging]
1National Center for Geriatrics and Gerontology (NCGG).
Abstract:
This review summarizes changes in bone mass and metabolism during natural aging of C57BL/6J mice and F344/N rats, as models of senile osteoporosis. The effects of caloric restriction, an evolutionally conserved remedy known to slow aging process and counter age-related disorders, on bone metabolism are also discussed.
