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Updated: Jun 4, 2026
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The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
Published on: May 16, 2016
[Animal models for bone and joint disease. Mouse models develop spontaneous osteoarthritis]
Ken Watanabe1, Yasuhiro Oue, Shiro Ikegawa
1Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology (NCGG).
Clinical Calcium
|February 4, 2011
Summary
Osteoarthritis (OA) is a common joint disease affecting the elderly. This study reviews spontaneous mouse models for OA research, highlighting the STR/ort strain for its natural disease onset.
Area of Science:
- Biomedical research
- Animal models in disease study
- Musculoskeletal disorders
Context:
- Osteoarthritis (OA) significantly impacts elderly quality of life.
- Animal models are crucial for understanding diseases like OA.
- Spontaneous OA models in mice include genetically modified and naturally occurring mutations.
Purpose:
- To review spontaneous osteoarthritis mouse models.
- To focus on the features and utility of the STR/ort mouse model.
- To provide insights into natural OA onset research.
Summary:
- Several mouse models exhibit spontaneous osteoarthritis.
- The STR/ort strain is a recognized model for natural OA onset.
- This review details various spontaneous OA models, emphasizing STR/ort.
Impact:
- Facilitates research into osteoarthritis pathogenesis.
- Supports the development of novel OA therapies.
- Enhances understanding of age-related joint diseases.
