Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relevance of Quantitative Measures of Beta-Cell Function in Clinical Practice.

Hormone research in paediatrics·2026
Same author

A one-week reduced-carbohydrate diet lowers insulin requirements and shifts the IGF axis with no detectable short-term change in endothelial function in a randomized, crossover trial of adults with type 1 diabetes.

Cardiovascular diabetology. Endocrinology reports·2026
Same author

Response to From Systemic B-Cell Targeting to Local Immune Engineering in Islet Transplantation.

Diabetes·2026
Same author

B Lymphocytes Impede Tregs to Erode Islet Tolerance in Type 1 Diabetes.

Diabetes·2025
Same author

Stage 1 type 1 diabetes memory B lymphocytes transcriptionally differ from healthy controls and harbor insulin-binding specificities.

ImmunoHorizons·2025
Same author

Use of Teplizumab to Modulate Stage 2 Type 1 Diabetes in Two Individuals With Autoimmune Polyendocrine Syndrome 1.

Diabetes care·2025
Same journal

TRABD2A promotes osteogenic differentiation of human periodontal ligament stem cells by modulating TNF-α and IL-1β.

Organogenesis·2026
Same journal

Thyroid cancer-derived exosomal SPP1 promotes tumor progression by driving macrophage M2 polarization through the CD44/JAK2/STAT3 signaling pathway.

Organogenesis·2026
Same journal

MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats.

Organogenesis·2026
Same journal

Adipose-derived mesenchymal stem cells-derived exosomes containing nano-pearl powder water-soluble matrix promote osteogenic differentiation of MC3T3-E1 cells.

Organogenesis·2026
Same journal

Comparison of vascular remodeling between a bioresorbable poly-L-lactic acid scaffold and a bare metal stent: a 6-month angiography and intravascular ultrasound analysis in porcine iliac arteries.

Organogenesis·2026
Same journal

Optimization of TX-100/SDS-based decellularized vascular material using ultrasound and chemical treatment: evaluation of structure and biosafety.

Organogenesis·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
11:57

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Can technological solutions for diabetes replace islet cell function?

Justin M Gregory1, Daniel J Moore

  • 1Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN, USA.

Organogenesis
|February 4, 2011
PubMed
Summary
This summary is machine-generated.

The artificial pancreas aims to restore normal blood glucose by mimicking insulin secretion. This technology offers a promising approach to managing diabetes and preventing complications.

Related Experiment Videos

Last Updated: Jun 4, 2026

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
11:57

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Diabetes Research

Background:

  • Diabetes mellitus is characterized by deficient insulin secretion, leading to hyperglycemia.
  • Restoring euglycemia is crucial for minimizing diabetes-related complications.
  • The artificial pancreas aims to replicate the function of pancreatic beta cells.

Purpose of the Study:

  • To review the progress in developing an artificial pancreas system.
  • To examine the technical design elements for imitating physiological insulin secretion.
  • To compare closed-loop control with other diabetes management strategies.

Main Methods:

  • Review of recent clinical trials utilizing closed-loop control systems.
  • Analysis of technical design principles for electromechanical beta-cell imitation.
  • Comparative assessment of artificial pancreas technology against islet transplantation and preservation.

Main Results:

  • Closed-loop control systems demonstrate significant advancements in glucose regulation.
  • The artificial pancreas shows potential for improving euglycemia.
  • Comparison highlights the artificial pancreas as a viable alternative to existing curative approaches.

Conclusions:

  • The artificial pancreas represents a significant step forward in diabetes management.
  • Further development and clinical validation are essential for widespread adoption.
  • This technology holds promise for effectively reestablishing euglycemia in individuals with diabetes.