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OUR EXPERIENCE HAS SHOWN THAT DETERMINING AN EFFECTIVE DAILY DOSE OF THEOPHYLLINE MEANS CONSIDERING SUCH FACTORS AS: age, patient's ideal weight, available pharmaceutical format, cost, frequency of administration, nicotine intake, coffee intake, diet and lifestyle. Cardiac and/or renal insufficiency and hepatic disorder are also factors affecting treatment with theophylline. We have therefore created a guide to daily dosage, taking all these factors into account. This helps both prescriber and pharmacist on instituting or evaluating theophylline treatment in an otherwise normal individual. This article presents the guide and explains the adjustment of dose in adult smokers, those with cardiac or renal insufficiency, and those with hepatic disorders.