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Association between dental pulp stones and calcifying nanoparticles
Jinfeng Zeng1, Fang Yang, Wei Zhang
1Department of Operative Dentistry and Endodontics, Guanghua School and Hospital of Stomatology and Institute of Stomatological Research, Sun Yat-sen University, Guangzhou, China.
International Journal of Nanomedicine
|February 4, 2011
Summary
Calcifying nanoparticles (CNPs) may cause dental pulp stones, a type of extraskeletal calcification. This study found CNPs in most analyzed dental pulp stones, suggesting their role in pulp calcification.
Area of Science:
- Biomineralization
- Dental Pathology
- Microbiology
Background:
- Dental pulp stones are a form of extraskeletal calcification with unknown etiology.
- Calcifying nanoparticles (CNPs), previously termed nanobacteria, are implicated in various calcification diseases.
Purpose of the Study:
- To investigate the potential role of CNPs in the formation of dental pulp stones.
- To determine the presence and characteristics of CNPs within human dental pulp stones.
Main Methods:
- Analysis of 65 human dental pulp stones.
- In situ detection of CNPs using immunohistochemical staining (IHS) and indirect immunofluorescence staining (IIFS).
- Transmission electron microscopy (TEM) for visualizing CNPs.
- Isolation and cultivation of CNPs from pulp stone samples.
Main Results:
- CNPs were detected in situ in 84.6% of samples via IHS and 92.3% via IIFS.
- Successful isolation and cultivation of CNPs were achieved in 88.2% of samples.
- TEM confirmed the presence of spherical CNPs (200-400 nm) with a crust in dental pulp stones.
Conclusions:
- CNPs can be detected and isolated from a high percentage of dental pulp stones.
- These findings suggest that CNPs play a significant role in the calcification process of dental pulp.
- CNPs are a potential etiological factor in the development of dental pulp stones.
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