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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
What has happened to people affected by thalidomide 50 years on?
A O'Carroll1, F O'Reilly, D L Whitford
1Royal College of Surgeons in Ireland, Dublin 2, Ireland. aocarroll@mountjoymed.ie
Introduction:
There have been reports of thalidomide-affected people suffering a deterioration in their disability over time [1, 2]. This study assessed changes in disabilities among thalidomide-affected people in the Irish population.
Methods:
A questionnaire, assessing musculo-skeletal health, quality-of-life, general health and illness intrusiveness was sent to 26 people affected by thalidomide in the Republic of Ireland.
Results:
Seventeen (65%) responded. Six (35%) respondents were not working as a result of their disability. Eleven (65%) reported a worsening of their disability over time, with nine of them reporting the deterioration as moderate to severe. The impact of this decline was measured by respondents in terms of ability to perform daily tasks, emotional health and finances (due to extra costs related to clothing, transport, housing alterations and heating).
Conclusion:
There is a need to continually review the physical, psychological and social needs of thalidomide survivors in order to ensure optimum care is made available.
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