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The role of transient receptor potential channels in respiratory symptoms and pathophysiology

M Allen McAlexander1, Thomas Taylor-Clark

  • 1Respiratory Discovery Biology, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA. michael.a.mcalexander@gsk.com

Advances in Experimental Medicine and Biology
|February 4, 2011
PubMed

Insights

Transient Receptor Potential (TRP) channels in the respiratory tract link irritant exposure and inflammation to airway sensitivity and airflow limitation. Research highlights their roles in both airway sensory nerves and non-excitable cells.

Area of Science:

  • Respiratory physiology
  • Ion channel research
  • Molecular biology

Background:

  • Transient Receptor Potential (TRP) channels are a diverse superfamily of ion channels.
  • TRP channels are increasingly recognized for their presence and function within the respiratory system.

Purpose of the Study:

  • To review the current understanding of TRP channel roles in the respiratory tract.
  • To emphasize the involvement of TRP channels in airway sensory nerves and non-excitable cells.

Main Methods:

  • Pharmacological studies
  • Genetic research
  • Literature review

Main Results:

  • TRP channels are widely distributed in the respiratory tract.
  • These channels connect noxious stimuli and inflammation to airway hyperresponsiveness, remodeling, and airflow obstruction.
  • TRP channels play significant roles in both airway sensory neurons and non-neuronal cells.

Conclusions:

  • TRP channels are critical mediators of respiratory responses to irritants and inflammation.
  • Further research into TRP channel function is essential for understanding and treating respiratory diseases.

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