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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Asymmetric total synthesis of danicalipin A and evaluation of biological activity
Taiki Umezawa1, Masayuki Shibata, Kensuke Kaneko
1Division of Environmental Materials Science, Graduate School of Environmental Science, Hokkaido University, Sapporo, Japan. umezawa@ees.hokudai.ac.jp
Organic Letters
|February 5, 2011
Abstract:
Asymmetric total synthesis of danicalipin A was achieved. The synthesis was characterized by diastereoselective introduction of chlorine atoms. Biological activities with synthetic danicalipin A, its enantiomer, and racemate were also evaluated toward brine shrimp. Both enantiomers of danicalipin A showed almost the same activity.
