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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

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Related Experiment Video

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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

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Published on: May 15, 2013

Experimental protocols and preparations to study respiratory long term facilitation.

Jason H Mateika¹, Kulraj S Sandhu

¹Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, United States. jmateika@med.wayne.edu

Respiratory Physiology & Neurobiology

|February 5, 2011

Summary

Respiratory long-term facilitation (LTF) is a key neural plasticity mechanism. This review evaluates models and protocols for studying LTF, aiming to standardize research for better comparisons.

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Area of Science:

Neuroscience
Respiratory Physiology

Background:

Respiratory long-term facilitation (LTF) is a neuronal plasticity phenomenon.
LTF involves increased respiratory motor output after intermittent hypoxia exposure.
It's characterized by sustained respiratory activity and nerve discharge increases.

Purpose of the Study:

To review and critically analyze models, preparations, and protocols used to study LTF.
To identify strengths and weaknesses of existing research methodologies.
To provide recommendations for standardized LTF research.

Main Methods:

Review of scientific literature spanning approximately 30 years.
Analysis of various animal models (cats, rats, humans) and experimental preparations.
Evaluation of different intermittent hypoxia protocols.

Main Results:

Diverse models and protocols have been employed, each with unique advantages and limitations.
Significant variations exist in how LTF is studied across different research groups.
A need for standardization to ensure comparable and reproducible results is evident.

Conclusions:

Standardized models and protocols are crucial for advancing the understanding of respiratory long-term facilitation.
Future research should focus on adopting consistent methodologies for reliable comparisons.
This review offers guidance for selecting optimal experimental designs for LTF studies.