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Updated: Jun 4, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
The systematic review of literature: synthesizing evidence for practice
1The University of Texas at Austin School of Nursing, USA. ellerew@mail.utexas.edu
Purpose:
With current emphasis on evidence-based practice, nurses are searching for answers to questions generated at the bedside. One method to identify and evaluate the existing evidence is to conduct or read a systematic review of the literature. The purpose of this paper is to describe the process of conducting a systematic review of literature.
Conclusion:
Defining attributes, rationale for, and steps in conducting systematic reviews are presented. Examples from published reviews on pediatric nursing are included.
Practice Implications:
Pediatric nurses may consult professionally prepared systematic reviews, such as The Cochrane Collection, or conduct their own reviews with the help of electronic search engines.
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