Related Experiment Video
Updated: Jun 4, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic mouse model
Roberta Corona1, Jasper Verguts, Ron Schonman
1Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium. coronaroberta@gmail.com
Objective:
To investigate acute inflammation in the peritoneal cavity in adhesion formation.
Design:
Prospective randomized, controlled trial.
Setting:
University laboratory research center.
Animal(S):
9- to 10-week-old BALB/c female mice.
Intervention(S):
In a laparoscopic mouse model, acute inflammation in the peritoneal cavity evaluated in CO(2) pneumoperitoneum enhanced adhesions, by CO(2) pneumoperitoneum plus manipulation, and in the latter group plus dexamethasone.
Main Outcome Measure(S):
Qualitative and quantitative adhesion scores and an acute inflammation score (neoangiogenesis, diapedesis, and leukocyte accumulation).
Result(S):
Adhesions at the lesion site were enhanced by the CO(2) pneumoperitoneum, further enhanced by manipulation, and decreased by the administration of dexamethasone. The acute inflammation scores (total, neoangiogenesis, diapedesis, and leukocyte accumulation) strongly correlated with the total adhesion score. Inflammation scores were similar at both the surgical lesion and the parietal peritoneum.
Conclusion(S):
Acute inflammation of the entire peritoneum cavity is an important mechanism involved in adhesion formation and enhances adhesion formation at the lesion site.
