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Updated: Jun 4, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
Published on: December 2, 2011
Understanding protein adsorption phenomena at solid surfaces
Michael Rabe1, Dorinel Verdes, Stefan Seeger
1Institute of Physical Chemistry, University of Zurich, Switzerland.
Abstract:
Protein adsorption at solid surfaces plays a key role in many natural processes and has therefore promoted a widespread interest in many research areas. Despite considerable progress in this field there are still widely differing and even contradictive opinions on how to explain the frequently observed phenomena such as structural rearrangements, cooperative adsorption, overshooting adsorption kinetics, or protein aggregation. In this review recent achievements and new perspectives on protein adsorption processes are comprehensively discussed. The main focus is put on commonly postulated mechanistic aspects and their translation into mathematical concepts and model descriptions. Relevant experimental and computational strategies to practically approach the field of protein adsorption mechanisms and their impact on current successes are outlined.
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