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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Susceptibility patterns of coagulase-negative staphylococci to several newer antimicrobial agents in comparison with

J Ian Stuart1, Michael A John, Sue Milburn

  • 1Department of Microbiology, London Health Sciences Centre, London, Ontario, Canada.

International Journal of Antimicrobial Agents
|February 8, 2011
PubMed

Insights

Newer antibiotics like telavancin and daptomycin show promising in vitro activity against challenging coagulase-negative staphylococci (CoNS) infections, offering alternatives to older drugs with increasing resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Coagulase-negative staphylococci (CoNS) are significant causes of hospital-acquired infections.
  • Increasing resistance to methicillin and other penicillins, alongside elevated vancomycin MICs, complicates CoNS treatment.
  • Emergence of novel antibiotics necessitates evaluation against prevalent pathogens.

Purpose of the Study:

  • To evaluate the in vitro efficacy of telavancin, daptomycin, linezolid, and tigecycline.
  • To compare these newer agents against oxacillin and vancomycin.
  • To assess activity against a large collection of clinical CoNS isolates.

Main Methods:

  • Agar dilution method used for susceptibility testing.
  • Tested 653 non-duplicate clinical isolates of CoNS.
  • Validated daptomycin testing with parallel Etest results.

Main Results:

  • Oxacillin exhibited the highest MIC variability; mecA gene presence increased oxacillin MICs.
  • Telavancin showed lower MICs than vancomycin (1-2 dilutions).
  • Daptomycin demonstrated broad activity, particularly against specific CoNS species; linezolid and tigecycline had restricted within-species MIC variation, except for certain species with higher tigecycline MICs.

Conclusions:

  • Telavancin, daptomycin, linezolid, and tigecycline represent viable therapeutic options for CoNS infections.
  • Daptomycin exhibits potent activity across various CoNS species.
  • Understanding antibiotic susceptibility patterns is crucial for effective CoNS management.

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