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Updated: Jun 4, 2026

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

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Published on: February 11, 2014

[Bladder necrosis after an immediate post-operative mitomycin C instillation].

J Branchereau¹, F Luyckx, M Hitier

¹Service d'Urologie, CHU Hôtel-Dieu, 44000 Nantes, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie

|February 8, 2011

Summary

Intravesical mitomycin C can reduce non-muscle-invasive bladder tumor recurrence. However, a rare case of bladder necrosis occurred after immediate instillation, necessitating cystectomy.

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Last Updated: Jun 4, 2026

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Published on: February 11, 2014

Area of Science:

Urology
Oncology
Chemotherapy

Background:

Intravesical chemotherapy with mitomycin C is a standard treatment for non-muscle-invasive bladder cancer.
It is administered to reduce the risk of tumor recurrence after surgical resection.

Observation:

A patient developed complete bladder necrosis following an immediate adjuvant instillation of mitomycin C.
The necrotic tissue could not be resected, leading to a total cystectomy and intestinal reconstruction.

Findings:

This case report highlights a rare but severe complication of intravesical mitomycin C.
A literature review identified four similar cases of bladder or lower urinary tract necrosis, all occurring despite adherence to early instillation protocols.

Implications:

Clinicians should be aware of the potential for bladder necrosis as a severe adverse event of intravesical mitomycin C.
Further research may be needed to understand the risk factors and optimal management strategies for this complication.