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Acute Pharyngitis01:30

Acute Pharyngitis

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State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior
12:38

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior

Published on: December 28, 2010

[PHACES syndrome].

J Morcillo Azcárate1, J Bernabeu-Wittel, I Fernández-Pineda

  • 1Servicio de Cirugía Pediátrica, Comité Multidisciplinar de Anomalías Vasculares, Hospital Infantil Universitario Virgen del Rocío, Sevilla. thelmar_arg@yahoo.es

Cirugia Pediatrica : Organo Oficial De La Sociedad Espanola De Cirugia Pediatrica
|February 9, 2011
PubMed
Summary
This summary is machine-generated.

PHACES syndrome, a condition linking facial hemangiomas with other abnormalities, requires thorough diagnosis. Early, multidisciplinary care and propranolol show promise for better patient outcomes.

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Area of Science:

  • Pediatric Neurology
  • Cardiology
  • Dermatology

Background:

  • PHACES syndrome is a complex disorder characterized by segmental facial hemangiomas and extracutaneous anomalies.
  • These anomalies can affect cerebral, cardiovascular, and ocular structures, as well as aortic and cranial arteries.

Observation:

  • A retrospective study analyzed four pediatric cases of PHACES syndrome.
  • Patients presented with facial hemangiomas, cerebral vascular malformations, structural cardiopathies, and ocular anomalies (microphthalmia).
  • Ventral wall defects were not observed in this cohort.

Findings:

  • Treatment involved corticosteroids (methylprednisolone, prednisone) and propranolol.
  • Propranolol demonstrated efficacy in halting tumor growth and promoting lesion regression with good tolerance.
  • Laser therapy was used for residual lesions in one patient.

Implications:

  • Early and comprehensive diagnostic evaluation is crucial for segmental facial hemangiomas to rule out PHACES syndrome.
  • A multidisciplinary approach involving various specialists facilitates earlier diagnosis and improved patient outcomes.
  • Propranolol emerges as a potentially effective therapeutic option for PHACES syndrome.