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Clostridium difficile and cytomegalovirus colitis co-infection: search for the hidden 'bug'

D F Florescu1, C Mindru, H E Chambers

  • 1Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5400, USA. dflorescu@unmc.edu

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|February 9, 2011
PubMed

Insights

Cytomegalovirus (CMV) and Clostridium difficile colitis co-infection is rare but important. Awareness is crucial, particularly for C. difficile colitis cases that do not respond to standard treatment.

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Virology

Background:

  • Cytomegalovirus (CMV) and Clostridium difficile are common pathogens.
  • Co-infection with both is infrequently reported.
  • C. difficile colitis often requires specific treatment protocols.

Observation:

  • Two new cases of concurrent CMV and C. difficile colitis are presented.
  • A review of seven previously published cases was conducted.
  • These cases highlight a potential diagnostic challenge.

Findings:

  • CMV infection can occur concurrently with C. difficile colitis.
  • Co-infection may present in patients with refractory C. difficile colitis.
  • The interaction between CMV and C. difficile in the colon warrants further investigation.

Implications:

  • Clinicians should consider CMV co-infection in severe or refractory C. difficile colitis.
  • Early diagnosis and appropriate treatment of CMV can improve patient outcomes.
  • Increased awareness may lead to better management strategies for this co-infection.

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