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Updated: Jun 4, 2026
07:17
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Understanding human T-cell-mediated immunoregulation through herpesviruses.
Scott R Burrows1, Denis J Moss, Rajiv Khanna
1Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. scott.burrows@qimr.edu.au
Immunology and Cell Biology
|February 9, 2011
Summary
Human herpesviruses establish lifelong infections controlled by T cells. New T-cell therapies offer revolutionary treatments for herpesvirus-associated diseases in clinical settings.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Human herpesviruses (HHVs) exhibit long-term coevolution with humans.
- Latent HHV infections are established within immune system cells.
- Asymptomatic persistent infections are regulated by CD8(+) and CD4(+) T cells.
Purpose of the Study:
- To overview the human immune system's interaction with latent herpesviruses.
- To explain the regulation of the lifelong host-virus relationship.
- To highlight clinical applications of T-cell-mediated immune regulation.
Main Methods:
- Review of extensive studies on T-cell-mediated immune regulation.
- Analysis of host-virus interactions in latent infections.
- Examination of clinical translation of immunological findings.
Main Results:
- T-cell responses are crucial for controlling persistent herpesvirus infections.
- Understanding immune regulation has led to clinical applications.
- T-cell-based strategies are effective in managing herpesvirus diseases.
Conclusions:
- T-cell-mediated immunity is key to managing latent human herpesviruses.
- Clinical applications of T-cell research are transforming patient care.
- Emerging T-cell therapies promise to revolutionize herpesvirus disease management.
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